934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
934-98-5, The dichloropyrimidine (3.29 gm, 0.01 moles) was dissolved in n-butanol (30 mL) and N-methyl-N’-(2-aminoethyl)piperazine (3.0 gm, 2.1 X 10″2 moles) was added. This mixture was heated to 1 15°C. forming a dark orange solution. After 2 hours, TLC (silica, 25percent methanol in methylene chloride) showed some remaining starting material along with a single product. Diisopropylethylamine (02.58 gm, 0.02 moles) was added along with additional N-methyl-N’- (2-aminoethyl)piperazine (1.0 gm, 7.0 X 10″3 moles) and this solution was heated at 1 15°C. for an additional 2 hours. After cooling the reaction was diluted with hexane (100 mL) and this solution was extracted with water (50 mL). The hexane solution was dried over magnesium sulfate, filtered and the solvents were removed under reduced pressure. The remaining orange solid was boiled in hexane (50 mL) and then cooled on ice. The solid was isolated by filtration, washed with hexane and dried. Yield was 3.0 gm, (55percent).
The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; JANUS BIOTHERAPEUTICS, INC.; LIPFORD, Grayson, B.; ZEPP, Charles, M.; WO2012/167053; (2012); A1;,
Piperazine – Wikipedia
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