With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.
115761-79-0, 5-CHLORO-2-FURAN-2-YL- [1, 2,4] triazolo [1, 5-a] pyrimidin-7-ylamine (1 g ; see Example L (b) above) was suspended in 22 mL OF DMSO along with 1.5 eq OF CSF ANZ 5 eq of aminoacetaldyde dimethyl acetal. The reaction mixture was stirred at 100 C for 10 hours. It was then cooled to room temperature and diluted with EtOAc and washed with H2O and brine, dried with NA2S04 and concentrated to afford N5-(2, 2- dimethoxy-ethyl)-2-furan-2-yl-[1, 2,4] triazolo [1, 5-a] pyrimidine-5,7-diamine. This dimethyl acetal intermediate (50 mg) was then unmasked to the corresponding aldehyde by suspending in a solution of 2 mL OF CH2CL2 and 0.2 mL of 2: 1 solution O : TFA/H20. The resulting reaction mixture was stirred at room temperature for 4 hours It was then neutralized with 0.3 mL OF ET3N. 1- (2, 4-Difluoro-phenyl) -piperazine (1.5 resulting reaction mixture was stirred at room temperature for 2 hours. It was then concentrated and then purified by preparative HPLC to afford the title compound. 1H NMR (DMSO-D6) 7.72 (d, J = 1.0 Hz, 1 H), 7.35 (br s, 2 H), 7.29 (d, J = 3.6 Hz, 1 H), 6. 7-7.4 (M, 3 H), 6.75 (dd, J = 3.6 Hz, 1.0 Hz, 1 H), 5.7 (S, 1H), 3.1 (BR S, 2 H), 2. 2- 3.6 (M, 12 H). MS : m/z: 441 [M + H]+.
As the paragraph descriping shows that 115761-79-0 is playing an increasingly important role.
Reference：
Patent; BIOGEN IDEC MA INC.; WO2004/92171; (2004); A2;,
Piperazine – Wikipedia
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