109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
a) (4-Methyl-3-oxo-piperazin-l-yl)-carbamic acid t-butyl ester l-Methyl-2-piperazinone hydrochloride (1 : 1) (300 mg, 1.99 mmol) was combined with dichloromethane (20 mL) to give a light yellow suspension. N,N-Diisopropylethylamine (309 mg, 417 ??, 2.39 mmol) was added at 0 C. Subsequently 3-(4-cyanophenyl)-2-oxaziridinecarboxylic acid 1,1-dimethylethyl ester (441 mg, 1.79 mmol) in dichloromethane (10 mL) was added during 35 min at 0C and the reaction mixture was stirred for 1 h at 0 C. Afterwards the reaction mixture was concentrated in vacuo and the residue was purified by flash chromatography (silica gel, 20g, 0% to 100% ethyl acetate in n-heptane) to deliver an oil contaminated with 4-cyano- benzaldehyde. This material was purified by a second chromatography (aminophase 5 g, ethyl acetate/n-heptane 1 / 1) to give the title compound (67 mg, 15%) as white solid; GC-MS (EI) 229.0 (M)+.
109384-27-2, The synthetic route of 109384-27-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; F. HOFFMANN-LA ROCHE AG; GRETHER, Uwe; HEBEISEN, Paul; MOHR, Peter; RICKLIN, Fabienne; ROEVER, Stephan; WO2013/37703; (2013); A1;,
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