Analyzing the synthesis route of 196811-66-2

196811-66-2, tert-Butyl 4-carbamothioylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-chloro-l-(4,5-dihydro-5-phenyl-3-isoxazolyl)ethanone (i.e. the product of Example 7, Step C) (0.450 g, 2.018 mmol) and 1,1-dimethylethyl 4-(amino- thioxomethyl)-l-piperazinecarboxylate (i.e. the product of Example 7, Step A) (0.5 g, 2.04 mmol) in ethanol (10 mL) was added triethylamine (0.204 g, 2.013 mmol), and the reaction mixture was stirred at room temperature for 12 h. The reaction mixture was concentrated 01464783 under reduced pressure, and the residue was partitioned between, ethyl acetate (30 mL) and water (30 mL). The organic layer was separated and washed with brine (25 mL), dried (Na2SO4), and. concentrated under reduced pressure. The crude residue was purified by column chromatography using 20 % ethyl acetate in petroleum ether as eluant to give 700 mg of the title compound as a white solid.1H NMR (CDCl3) delta 1.48 (s, 9H), 3.30 (m. IH), 3.54 (m, 8H)5 3.74 (m, IH)5 5.71 (m, IH)3 6.91 (s, IH), 7.40-7.29 (m, 5H).

196811-66-2, As the paragraph descriping shows that 196811-66-2 is playing an increasingly important role.

Reference：
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2008/13622; (2008); A2;,
Piperazine – Wikipedia
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