With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
4-Fluorobenzaldehyde15 (619 muL, 5.85 mmol), 1-acetylpiperazine (500 muL, 3.90 mmol) and Na2CO3 (620 mg, 5.85mmol) were dissolved in H2O (25 mL) and the stirred at 100C overnight. After extractionwith DCM, the combined organic layers were concentrated under reduced pressure and silicagel column chromatography (3% MeOH/DCM) yielded 17a (942 mg, 58%). 1H NMR (500MHz, DMSO-d6) delta 9.73 (s, 1H), 7.73 (d, J = 8.9 Hz, 2H), 7.04 (d, J = 8.9 Hz, 2H), 3.65-3.54 (m,4H), 3.50-3.44 (m, 2H), 3.42-3.36 (m, 2H), 2.04 (s, 3H); 13C NMR (126 MHz, DMSO-d6) delta190.2, 168.42, 154.3, 131.4, 126.4, 113.2, 46.3, 46.0, 44.9, 40.3, 21.1; HRMS (ESI-MS): Calculatedfor C13H17N2O2 [M+H]+: 233.12845; found: 233.12871.
13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Buehrmann, Mike; Wiedemann, Bianca M.; Mueller, Matthias P.; Hardick, Julia; Ecke, Maria; Rauh, Daniel; PLoS ONE; vol. 12; 9; (2017);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics