278788-66-2, (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of imidazole (15.7 g, 231 mmol) in DCM (100 mL) was added SOCh (8.25 g, 69.4 mmol, 5.03 mL) at 0 C. The reaction mixture was stirred at 15 C for 1 hour. To the mixture was added tert-butyl (3R)-3-(hydroxymethyl)piperazine-l-carboxylate (5 g, 23.1 mmol) in DCM (100 mL) at -70 C. The reaction mixture was stirred at 15 C for 12 hour. Upon completion, the reaction mixture was quenched by saturated NH4CI (100 mL) and separated, the aqueous layer was extracted with DCM (40 mL).The combined organic layers were washed with brine (20 mL), dried over Na2S04, filtered and concentrated under vacuum to give tert-butyl (3aR)-l-oxo-3a,4,6,7-tetrahydro-3H-oxathiazolo[3,4-a]pyrazine-5-carboxylate (5.8 g, 22.1 mmol, 95.6% yield) as a brown solid., 278788-66-2
278788-66-2 (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate 24820286, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; FISCHER, John, P.; FELL, Jay, Bradford; BLAKE, James, F.; HINKLIN, Ronald, Jay; MEJIA, Macedonio, J.; HICKEN, Erik, James; CHICARELLI, Mark, Joseph; GAUDINO, John, J.; VIGERS, Guy, P.A.; BURGESS, Laurence, E.; MARX, Matthew, Arnold; CHRISTENSEN, James, Gail; LEE, Matthew, Randolf; SAVECHENKOV, Pavel; ZECCA, Henry, J.; (529 pag.)WO2017/201161; (2017); A1;,
Piperazine – Wikipedia
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