103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5-Chloro-2-nitroaniline (2?g, 11.6?mmol) was taken in dry DMF (5?ml) and 2-piperazin-1-yl-ethanol (3g, 23.08?mmol) and K2CO3 (4.8?g, 34.6?mmol) were added to the solution. This mixture was then heated at 110?C under N2 atmosphere for 12?h until the disappearance of 5-chloro-2-nitroaniline. The crude compound was suspended in water and the product was extracted with ethyl acetate. The organic layer was washed twice with water, dried over anhydrous Na2SO4 and concentrated. This resulted in a pure product as confirmed by TLC (1% MeOH/CHCl3 on pre-coated silica gel) and was isolated as a bright yellow solid (2.93?g, 95% yield). 1H NMR (300?MHz, CDCl3) delta ppm 2.59-2.65 (m, 6H), 3.4 (t, J?=?4.8, 4H), 3.7 (t, J?=?4.8, 2H), 5.95 (d, J?=?2.7, 1H), 6.1 (bs, 2H, NH2), 6.29 (dd, J?=?9.3, J?=?2.7, 1H), 8.02 (d, J?=?9.3, 1H); HRMS: m/z = 267.1457 [M+H]+, Calcd. = 267.1457 [M+H]+; mp 163?C.
103-76-4, The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Kaulage, Mangesh H.; Maji, Basudeb; Pasadi, Sanjeev; Ali, Asfa; Bhattacharya, Santanu; Muniyappa; European Journal of Medicinal Chemistry; vol. 148; (2018); p. 178 – 194;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics