With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.
Example 1 Preparation of 4-[(4-methyl-1-piperazinyl)methyl]benzoic acid (formula (2)) 350 ml of ethanol was added to 155 g (1.547 mol) of N-methylpiperazine. At room temperature (25 ± 3C), 60 g (0.351 mol) of 4-chloromethylbenzoic acid was added thereto and stirred for 6-7 hours. The reaction was analyzed by HPLC, and then the reaction solution was distilled under reduced pressure to remove ethanol, and 60 ml of 1-butanol was added thereto. The mixture was azeotropically distilled at 70 ± 2C and concentrated to produce a solid. 600 ml of 2-propanol was added thereto and the mixture was stirred at room temperature (25 ± 3C) for 30 minutes, stirred under reflux for 15 minutes, and then stirred at room temperature (25 ± 3C) for 12 hours with slow cooling. The produced precipitate was cooled to 19 ± 3C, stirred for 1 hour and then filtered. The filtrate was washed with 50 ml of cooled 2-propanol and dried in an oven at 60C, thereby obtaining a white compound of formula (2) (60 g, yield: 72%, purity: 95% or higher). HPLC purity: 99.123% (desmethyl impurity: 0.042%, starting material 0.42%).
109-01-3, The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Bcworld Pharm. Co. Ltd.; EP2530077; (2012); A1;,
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