278788-66-2, (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate (1.68 g, 7.77 mmol) was added to 113 7-bromo-4,6-dichloro-8-fluoro-3-nitroquinoline (1.2 g, 3.53 mmol), and 56 DIPEA (1.571 ml, 8.83 mmol) in NMP (10 ml) under nitrogen, and the resulting solution was stirred at room temperature for 3 hours. The mixture was partitioned between ethyl acetate and water then the organic layer was washed with water (×2) then brine, dried and evaporated then purified by flash silica chromatography, elution gradient 10 to 40% 57 EtOAc in 58 heptane. Pure fractions were evaporated to dryness to afford 115 tert-butyl (R)-4-(7-bromo-6-chloro-8-fluoro-3-nitroquinolin-4-yl)-3-(hydroxymethyl)piperazine-1-carboxylate (0.96 g, 52%) as a yellow solid. m/z: ES+ [M+H]+ 521., 278788-66-2
The synthetic route of 278788-66-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Piperazine – Wikipedia
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