With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216144-45-5,4-(4-Methylpiperazin-1-yl)benzylamine,as a common compound, the synthetic route is as follows.
Stage 3: methyl 4-[2-[4-(4-methylpiperazin-1-yl)benzyl]amino-4-oxoquinazolin-3(4H)-yl]butanoateTriethylamine (0.4 mL) and [4-(4-methylpiperazin-1-yl)benzyl]amine (300 mg) are successively added to a solution of methyl 4-(2-chloro-4-oxoquinazolin-3(4H)-yl)butanoate (140 mg) in tetrahydrofuran (3 mL). The mixture is stirred at ambient temperature for 24 hours then water and ethyl acetate are added. After decantation and extractions, the combined organic phases are washed with salt water, dried over Na2SO4 then concentrated under reduced pressure at 40 C. Purification by flash chromatography on silica gel (eluent: dichloromethane/methanol 95:5) produces the expected compound in the form of beige crystals (131 mg, 58% yield from Stage 1).MS/LC: calculated MM=449.2; m/z=450.2 (MH+)NMR (1H, 400 MHz, DMSO-d6): delta 1.85 (t, 2H), 2.21 (s, 3H), 2.40 (m, 6H), 3.08 (m, 4H), 3.54 (s, 3H), 4.05 (t, 2H), 4.54 (d, 2H), 6.86 (AB, 2H), 7.08 (t, 2H), 7.18 (AB, 1H), 7.25 (AB, 2H), 7.48 (t, 1H), 7.52 (t, 1H), 7.89 (AB, 1H).
216144-45-5, The synthetic route of 216144-45-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SOCIETE DE CONSEILS DE RECHERCHES ET D’APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.); US2010/144714; (2010); A1;,
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