With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.
?To a solution 6-chiora-M-(3-nitrophenyl)pvrimidin-4-amine (1.0 g, 4.00 minol) in2 -hutanol (10 mL) and trifluoroacetic acid (0.3 mL) was added 2-methoxv-4.4-niethylpiperazin-i-yl)anihne (6o6irig, 4.39 inmol). The reaction mixture was stilTed at 120 C for 10 hrs and the solvent concentrated undcr reduced pressure. The reaction mixture was diluted with dichloromethane and washed with saturated aqueous potassium carbonate solution and brine. The organic layer was dried over Mg504, filtered through a pad of celiteand concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (1:99 to 3:97, ammonia solution 7.0 N in methanol/dichloromethane) to afford N4-(2-methoxy-4-(4-methyipiperazin- 1 -yi)phenyl)-N6- (3-nitrophenyflpyrimidine-4,6-dianiine (1.3 g, 75% yield) as an solid. Rt = 2.73 mm; ?H NMR 600 MHz (DMSO-d6) d 9.50 (s, lH), 8.72 Cc, lH), 8.24 (s, 1H), 8.22 (s, IH), 7.91 (dd, J::: 1.2 Fiz,J 8.4 Hz, iLl), 7.27 (d,J 8.4 Hz, HI), 7.50 (j,J::: 8.4 Hz, iLl), 7.21 (d,J 8.4 Hz, 1H), 6.49 (d,J= 2.4 Hz, 1H). 6.51 (dd,J= 2.4 Hz,J= 9.0 Hz, 1H), 5,76 (s, 1H), 3,77 (s, 3W). 3.16 (in, 4ff). 2,46 (rn, 4ff), 2.32 (s, 3H,); MS mAr: 436.45 [M+i].
122833-04-9, As the paragraph descriping shows that 122833-04-9 is playing an increasingly important role.
Reference：
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael; CHOI, Hwan Geun; TAN, Li; WO2015/6492; (2015); A1;,
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