4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Oxalyl chloride (47.7 kg, 375.8 mol) was added to a solution of oxazole-5-carboxylic acid (32.88 kg, 290.8 mol) in isopropyl acetate (144 kg) maintaining the temperature at 52-58 °C. The temperature was increased to 58.5 °C, stirred for 5 h and then cooled to 20 °C. The reactionmixture was added to a solution of 1-(isopropyl)piperazine (41 kg, 319.8 mol) and potassium carbonate (118.4kg) in isopropyl acetate (348 kg) and water (103 kg) maintaining the temperature below 25 °C. The reaction was stirred for 15 mins, the temperature was increased to 33 °C and the organic phase washed with water (191 kg), concentrated under reduced pressure to 95 L and cooled to 20 °C. n-Heptane (157 kg) was added and the crystallisation stirred for 2 h, and theproduct filtered off, washed with n-heptane (157 kg) and dried under vacuum 40 °C to give the title compound (57.14 kg, 88.0percent).1H NMR (400 MHz, CDCI3-d) ppm 7.94 (5, 1 H), 7.56 (5, 1 H), 3.91-3.73 (m, 4 H), 2.75 (spt., J=6.5 Hz, 1 H), 2.63-2.52 (m, 4 H) and 1.06 (d, J=6.6 Hz, 6 H)., 4318-42-7
The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BREAM, Robert Nicholas; HAYLER, John David; IRONMONGER, Alan Geoffrey; SZETO, Peter; WEBB, Michael Robert; WHEELHOUSE, Katherine Marie Penelope; WILLACY, Robert David; (50 pag.)WO2016/193255; (2016); A1;,
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