75336-86-6,75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Part A Synthesis of (R)-1-(3-Chloro-pyridin-2-yl)-3-methyl-piperazine: Dissolve 2,3-dichloropyridine (8.5 g, 0.057 moles) and (R)-(-)-2-methylpiperazine (5.75 g, 0.057 moles) in N,N-dimethylacetamide (125.0 mL) under nitrogen atmosphere. Add anhydrous powdered K2CO3 (23.75 g, 0.172 moles) to this mixture and stir at 135-140° C. for 48 h. New spot noticed in TLC (5percent MeOH / CHCl3 / 1percent NEt3) along with absence of starting materials. Cool the reaction mixture to room temperature, dilute with water (400 mL), extract with EtOAc (3*200 mL) and wash the combined organic extract with brine (2*150 mL). Dry over MgSO4, concentrate under vacuum to afford crude product (20.0 g) as orange yellow liquid. Distil the crude under high vacuum to afford pyridylpiperazine derivative as yellow viscous oil (10 g, bp 112-115° C. /0.1 torr). NMR (CDCl3): delta.. 1.1-1.12 (d, 3H, J=1.6 Hz), 2.50-2.53 (t, 1H), 2.83-2.87 (m, 1H), 3.06-3.08 (m, 3H), 3.67-3.75 (m, 2H), 6.80-6.82(dd, 1H), 7.56-7.58 (dd, 1H), 8.17-8.18 (dd, 1H).
As the paragraph descriping shows that 75336-86-6 is playing an increasingly important role.
Reference:
Patent; Bakthavatchalam, Rajagopal; Hutchison, Alan; DeSimone, Robert W.; Hodgetts, Kevin J.; Krause, James E.; White, Geoffrey G.; US2002/132853; (2002); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics