With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.
A 250 mL round bottom flask was charged with 20 mmol of compound (4), 80 mL of 1,4-dioxane,20 mmol of compound (2) (R is methyl) was added dropwise at 20 C under stirring for 1 hour. The mixture was heated to reflux for further stirring. After about 6 hours, the solid was no longer increased but changed to distilled. The methanol was distilled off to recover the compound (2) (R is methyl), cooled to below 30 , 40mmol sodium methylate in methanol 30% sodium methoxide was added dropwise over about 1 hour and then stirred for 1 hour, the temperature was rectified methanol were recovered, 1 , 4-dioxane and piperazine (3). The product was distilled off under reduced pressure to give a pale yellow transparent liquid to obtain piperazine methylmethyldimethoxysilane (R is methyl) represented by the formula (1) a, the yield of 95% (as (2) dollars), high performance liquid chromatography analysis content of 98.7%.
142-64-3, The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Yancheng Technology College; Sun Guoxiang; (6 pag.)CN106046041; (2016); A;,
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