With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235865-77-6,2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.
Formula 2(100 g) and triethylamine (35.2 g) was stirred in dichloromethane (500 mL). In another flask, formula 9(46.9 g), 4-dimethylaminopyridine (42.68 g), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide(46.96 g) in dichloromethane (1.2 L) was stirred. The solution of formua-2 was added slowly to the solution of formula 9 at ambient temperature and the reaction was stirred for 12 hours. The organic layer was washed with 10% acetic acid solution (750 mL) twice, followed by 5% aqueous NaHCO3 (750 mL) and 5% aqueous NaCI (750 mL). The dichloromethane layer was concentrated under vacuum at 40C. Dichloromethane (900 mL) was added and the r eaction mixture was heated to 38C. Methanol (100 mL) and ethyl acetate (800 mL) were added at 38 The reaction mass was cooled to 27±3C, stirred for 2 hours, and filtered. The solid was washed with a mixture of dichloromethane (150 mL) and ethyl acetate (150 mL). The solid was dried under vacuum at 60±5C for 4 hours. Dry weight: 76 g (Yie Id = 50%)., 1235865-77-6
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Reference：
Patent; MYLAN LABORATORIES LIMITED; JOSHI, Rajesh; TRIPATHI, Anil Kumar; CHAUDHARI, Chandrakant; GOTTUMUKKALA, Nagaraju; POKHARKAR, Kiran; SANGVIKAR, Yogesh; VADALI, Lakshmanarao; JAYACHANDRA, Suresh Babu; (48 pag.)WO2018/29711; (2018); A2;,
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