848482-93-9, (S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
848482-93-9, To a stirred solution of (S)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (CAS Number 848482-93-9; 0.540 g, 2.35 mmol) in MeOH (15 ml) was added 37% aqueous formaldehyde solution (0.2 ml) and a catalytic amount of acetic acid, followed by 10% dry Pd/C (0.100 g) under nitrogen atmosphere at rt. The reaction mixture was purged with H2 gas at rt for 2 h. The resulting reaction mixture was carefully filtered through celite hyflow and the filtrate was concentrated under reduced pressure. The residue was triturated with n-pentane (5 ml) to obtain a solid material, which was dried under high vacuum to yield (S)-4-(tert-butoxycarbonyl)-1 – methylpiperazine-2-carboxylic acid (0.300 g, 1 .23 mmol). This material was used directly for the next step without further purification. LCMS: Method C, 1 .560 min, MS: ES+ 245.33.
848482-93-9 (S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid 1501850, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; MISSION THERAPEUTICS LIMITED; STOCKLEY, Martin Lee; KEMP, Mark Ian; MADIN, Andrew; (167 pag.)WO2018/65768; (2018); A1;,
Piperazine – Wikipedia
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