5625-67-2, Piperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5625-67-2
Step 1: tert-Butyl-3-oxopiperazine-1-carboxylate To a solution of piperazin-2-one (22.00 g, 219.7 mmol) in THF (300 mL) was added a mixture of NaHCO3 (29.53 g, 307.6 mmol) in H2O (100 mL), (Boc)2O (43.16 g, 197.8 mmol), then the reaction solution was stirred at rt for 16 h. The mixture was concentrated, poured into water (100 mL) and extracted with EtOAc (100 mL*2). The combined organic layers were dried over Na2SO4, filtered and concentrated to obtain tert-butyl-3-oxopiperazine-1-carboxylate (40.00 g, 90.91%) as white solid. ESI-MS (EI+, m/z): 145.2[M+H-56]+. 1H NMR (500 MHz, CDCl3) delta 4.08 (s, 2H), 3.62 (t, J=5.2 Hz, 2H), 3.37 (s, 2H), 1.47 (s, 9H).
The synthetic route of 5625-67-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Navitor Pharmaceuticals, Inc.; O’Neill, David John; Saiah, Eddine; Kang, Seong Woo Anthony; Brearley, Andrew; Bentley, Jonathan; (519 pag.)US2018/127370; (2018); A1;,
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