With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Compound 2Sa (3.0 g, 18.8 mmol), compound 2Sb (3.0 g, 13.8 mmol, 100% ee) and potassium hydroxide (2.4 g, 42.8 mmol) were added sequentially to 30 mL DMSO while stirring. The reaction mixture was heated to 30C. for 3 hours and then warmed to 60C. for 5 hours. After completion of the reaction, the system was cooled to room temperature, 300 mL of water was added, precipitation formed, and stirring was continued at room temperature overnight. Solid was collected via filtering, and and was added to 25 mL of a mixed solvent consisting of 5:1 petroleum ether:ethyl acetate, and stirred at room temperature for half an hour. The solid was collected via filtering, and was dried to give compound 2Sc (3.0 g, yield 64%) as a yellow solid. MS 336.2 [M+H]+.
314741-40-7, As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.
Reference：
Patent; Hangzhou Innogate Pharma Co., Ltd.; ZHANG, Hancheng; LIU, Shifeng; (40 pag.)US2019/100531; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics