381242-61-1, 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A mixture of 1-bromo-2-chloroethane (0.43 mL, 5.2 mmol),K2CO3 (0.71 g, 5.2 mmol) in ACN (10 mL) was stirred at 50 C for15 min and then 1-(2-methoxyphenyl)piperazine (4, 0.5 g,2.6 mmol) in ACN (5 mL), was added dropwise within 1 h duration.Reaction mixture was further stirred for 4 h. Then the mixture wasconcentrated under reduced pressure and residue was dissolved inEtOAc (15 mL) and the EtOAc layer was then washed with water(10mL x 3). The combined organic layer was dried (anhyd. Na2SO4)and concentrated under reduced pressure. The resultant waswashed with distilled hexane and again dried under high vaccum.The pure offwhite crystals were obtained by recrystallization usingEtOAc/Hexane (yield: 69%).
381242-61-1, 381242-61-1 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine 2771413, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Gupta, Sonal; Pandey, Deepti; Mandalapu, Dhanaraju; Sharma, Vikas; Shukla, Mahendra; Singh, Seema; Singh, Nidhi; Yadav, Santosh Kumar; Tanpula, Dilip Kumar; Singh, Surabhi; Maikhuri, Jagdamba P.; Shukla, Shubha; Lal, Jawahar; Siddiqi, Mohammad I.; Gupta, Gopal; Sharma, Vishnu L.; European Journal of Medicinal Chemistry; vol. 132; (2017); p. 204 – 218;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics