With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.
The intermediate N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]- 4-quinazolinamine 10 (9.26 g, 1.13 mol) was mixed with 4-methyl-1-piperazinyl-ethanol 11 (10.5 g, 1.5 mol), mixed and stirred in the presence of 80percent concentrated sulfuric acid (100 ml) and rapidly heat to 140°C, an intermolecular dehydration reaction occurs to produce N-(5-chloro-1,3-benzodioxolane-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(4- Hydrogen-2H-pyran-4-yl)oxy]-4-quinazolinamine 12 (16.1 g, 1.86 mol)., 5464-12-0
Big data shows that 5464-12-0 is playing an increasingly important role.
Reference：
Patent; Hu Zhangyan; (10 pag.)CN107814793; (2018); A;,
Piperazine – Wikipedia
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