Simple exploration of 216144-45-5

As the paragraph descriping shows that 216144-45-5 is playing an increasingly important role.

216144-45-5, 4-(4-Methylpiperazin-1-yl)benzylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 8-bromo-2-(chloromethyl)benzofuro[3,2-d]pyrimidin-4(3H)-one 6 (70 mg, 0.22 mmol) in 1.5 mL anhydrous DMF was added (4-(4- methylpiperazin-l-yl)phenyl)methanamine (50 mg, 0.22 mmol) and Cs2CO3 (143 mg, 0.44 mmol). The reaction mixture was heated to 85 0C at 150 W for 10 minutes in a CEM-Discover microwave reactor. The reaction mixture was filtered and concentrated in vacuo. Purification by preparative HPLC, followed by concentration in vacuo and lyophilization afforded the title compound (18.2 mg, 17%) as a white solid. 1H NMR (400 MHz, d6-DMSO): 8.16 (m, IH), 7.79 (m, 2H), 7.19 (d, 2H), 6.86 (d, 2H), 3.72 (s, 2H), 3.68 (s, 2H), 3.07 (m, 4H), 2.50 (m, 4H), 2.21 (s, 3H), 1.90 (s, 3H); MS (EI) for C23H24BrN5O2: 482 (MH+)., 216144-45-5

As the paragraph descriping shows that 216144-45-5 is playing an increasingly important role.

Reference：
Patent; EXELIXIS, INC.; WO2009/86264; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics