With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109384-27-2,1-Methylpiperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.,109384-27-2
EXAMPLE 21b (4-methyl-3-oxopiperazin-1-yl)acetic acid The compound can be prepared in the following way: A solution of 0.61 g of 2-bromoacetic acid, 10 ml of water, 0.74 g of 1-methyl-piperazin-2-one hydrochloride (commercially available product) and 0.61 g of potassium carbonate is kept stirred at a temperature in the vicinity of 20 C. for 18 hours. 0.31 g of potassium carbonate is then added and stirring is maintained for one hour. The reaction medium is acidified (pH~1) by addition of an aqueous hydrochloric acid solution (1N) and then concentrated by evaporation under reduced pressure. The residue obtained is taken up in 2 times 30 ml of toluene and then concentrated. The yellow solid obtained is taken up in 5 ml of ethanol, filtered off on a sintered glass funnel and washed with 2 times 5 ml of ethanol. The filtrate is concentrated by evaporation under reduced pressure and 1.03 g of (4-methyl-3-oxopiperazin-1-yl)acetic acid hydrochloride are thus obtained in the form of a yellow foam. MS: method A; [M+H]+: m/z=173; [M-H]-: m/z=171; Tr=0.11 min.
The synthetic route of 109384-27-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; sanofi-aventis; US2011/263593; (2011); A1;,
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