55112-42-0, 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,55112-42-0
Example 4: Preparation of Zopiclone in CH2CI2[0067] A slurry of l-chlorocarbonyl-4-methyl piperazine hydrochloride(19.627g) in CH2Cl2 (200ml) was stirred mechanically and cooled to 50C. Then tri- ethyl amine (Et3N) (17.7Ig) was added to the slurry over 25 min. During Et3N addition, there was no temperature rise. After Et3N addition ended, DMAP (1.85g) was added to the slurry, and after 1-2 min of stirring, 7-OH-Py (2Og) was added. The slurry changed its appearance at DMAP addition. The reaction mixture was heated to room temperature and stirred for 6h. After 6h the stirring was continued at reflux for Ih. The reaction mixture was cooled to about 200C and water was added (70 ml). Phases were separated, .with an inter-phase left in organic phase. Organic phase was washed with H2O (2×70 ml). Inter-phase was filtered. Organic phase was dried over MgSO4, filtered and the solvent was evaporated to dryness on rotavapor to give zopiclone crude product (28.94 g, yield 95%; purity 98.69% by HPLC).
55112-42-0 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride 3016934, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2008/2629; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics