216144-45-5, 4-(4-Methylpiperazin-1-yl)benzylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 1-chloro-4-methoxy-5-nitro-2-vinylbenzene (0.42 g,1.95 mmol), 4-(4- methyl-piperazin-1-yl)-benzylamine (1.2 g, 5.85 mmol) and quinol (0.043 g, 0.39 mmol) in n-butanol (8 mL) was heated to reflux for 12 hours under a N2 atmosphere. Water (100 mL) was added and the reaction mixture extracted with EtOAc (3 X 100 mL). The combined organic extracts were washed with brine (50 mL), dried (Na2S04) and concentrated under reduced pressure. The residue was purified by columnchromatography on neutral silica gel using 3-5% methanol in DC to give the title compound (0.35 g, 43%) as a solid.
216144-45-5, As the paragraph descriping shows that 216144-45-5 is playing an increasingly important role.
Reference：
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert George; WALKER, David Winter; BOYCE, Richard Justin; WO2011/141716; (2011); A2;,
Piperazine – Wikipedia
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