Some tips on 1-Isopropylpiperazine

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4318-42-7

Step B/lntermediate B108: 1-(3-chloro-2-methyl-4-nitrophenyl)-4-(1- methylethyl)piperazine; To the solution of 2-chloro-4-fluoro-3-methyl-1 -nitrobenzene (12.5 g, 64.8 mmol, 1.2 equiv.) and isopropylpiperazine (10.8 g, 53.98 mmol, 1 equiv.) in 90 mL of anhydrous DMSO was added powdered K2CO3 (37 g, 269 mmol, 5 equiv.). The mixture was stirred at 40~50°C overnight before it was poured into 200 ml. of ice-water. The precipitates were collected and purified via chromatography on SiO2 to afford 1-(3- chloro-2-methyl-4-nitrophenyl)-4-(1-methylethyl)piperazine as a yellow solid (12.7g, 79percent Yield). 1 H NMR (400 MHz, CDCI3) delta ppm 0.95-1.05 (d, J=6.53Hz, 6H), 2.31 (s, 3H), 2.60-2.72 (m, 5H), 2.89-2.95 (m, 4H), 6.87 (d, J=8Hz, 1 H), 7.62 (d, J=8Hz, 1 H).

4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/20990; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics