109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[Example 62] 1- [5- (1-Methyl-1H-pyrrol-3-yl) -1- (pyridin-3-yl) – 1H-pyrazole-3-carbonyl]-4-methyl-3-oxopiperazine [Show Image] [Show Image] 1-Hydroxybenzotriazole (0.132 g), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.378 g), triethylamine (0.630 mL), and 1-methylpiperazin-2-one hydrochloride (0.200 g) obtained from Referential Example 15 were added at room temperature to a solution of 5-(1-methylpyrrol-3-yl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid (0.242 g) obtained from Referential Example 38 in N,N-dimethylformamide (5.0 mL), and the mixture was stirred for 3 days. The reaction mixture was partitioned between water and ethyl acetate, and the aqueous layer was further extracted with ethyl acetate. The organic layers were combined, and the combined organic layer was washed with saturated brine, followed by drying over sodium sulfate anhydrate. After a filtration step, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform – methanol), to thereby give the title compound (0.243 g, 74%) as an amorphous product. 1H-NMR(400MHz,CDCl3)delta:3.01(3H,s), 3.46(2H,br), 3.61(3H,s), 4.03(1H+1H×1/3,m), 4.42(1H+1H×2/3,m), 4.80(1H,br), 5.86(1H,br), 6.46-6.56(2H,m), 6.82(1H×2/3,br), 6.86(1H×1/3,br), 7.37-7.46(1H,m), 7.76-7.95(1H,m), 8.61-8.78(2H,m). ESI-MS m/z:365(M+H.)+., 109384-27-2
The synthetic route of 109384-27-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1762568; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics