With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.
The (R) – 1-BOC-3-methyl-piperazine (300 mg, 1 . 5mmol) dissolved in acetonitrile (10 ml) in, adding DIEA (390 mg, 3mmol) and cyclopropyl methyl bromide (235 mg, 1 . 73mmol), 40 C reaction 2d, cessation of the reaction, the reaction liquid concentrated, column chromatography (DCM: the MeOH=40 […] 1) obtaining white semi-solid 320 mg, yield 84.2%., 163765-44-4
The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Institute Of Materia Medica Chinese Academy Of Medical Sciences; Xu, Bailing; Chen, Xiaoguang; Yao, Haiping; Ji, Ming; Jin, Jing; Zhou, Jie; Wang, Ke; Zhao, Dalong; (55 pag.)CN105461697; (2016); A;,
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