With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-70-5,tert-Butyl 4-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Compound lOA was treated with 30 mL EA solution of HCl (1 M) and stirred at rt for18.5 hrs. The mixture was concentrated in vacuo to give about 135 mg of 1-benzylpiperazine(Compound lOB) as a white solid which was used directly in the next step. MS: calc’d 177(M+Ht, measured 177 (M+Ht.
57260-70-5, The synthetic route of 57260-70-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; WANG, Lisha; YUN, Hongying; ZHANG, Weixing; ZHU, Wei; ZHANG, Zhiwei; (69 pag.)WO2017/202704; (2017); A1;,
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