With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.
7-Bromo-1-methyl-1H-indole-2-carboxylic acid (2.5 g, 10 mmol), 4-((4-methylpiperazin-1-)methyl)-3-(trifluoromethyl) Aniline (2.73g, 10mmol) and2-(7-Oxobenzotriazole)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (HATU) (3.8 g, 10 mmol)Dissolved in N,N-dimethylformamide, added diethyl isopropylamine (1.65 mL, 10 mmol), stirred until the reaction was completed.Extracted with ethyl acetate and water, the organic phase was concentratedColumn chromatography gave product 3.6 g, yield 70%., 694499-26-8
As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.
Reference：
Patent; Beijing Seth Ming Qiang Pharmaceutical Technology Co., Ltd.; Zhang Qiang; Zhang Hongbo; Zhou Likai; Feng Shouye; Yang Hailong; Wang Zhongxiang; (54 pag.)CN109988151; (2019); A;,
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