122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a mixture of pyrimidine analogues 34, 35 or 36 (1.56 g, 5.45 mmol), amino piperazine 38 (1.21 g, 5.45 mmol) and anhydrous 2-butanol (30 mL) was added trifluoroacetic acid (0.42 mL, 5.45 mmol). The reaction mixture was heated to 100 C and stirred for 4 h. Subsequently, it was cooled to room temperature and was basified (pH 8.0) by dropwise addition of saturated aqueous sodium bicarbonate solution. The 2-butanol was removed in vacuo to obtain a thick slurry which was dissolved in ethyl acetate (50 mL). The organic layer was washed with water (3 x 20 mL) and brine (1 x 20 mL). The combined organic extracts were dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The crude product was purified by flash silica gel chromatography using dichloromethane-methanol (25:1, v/v) as eluent to afford the nitro analogues as brown solids in yields ranging from 72 – 79%.5-Chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(2-nitrophenoxy)pyrimidin-2-amine (3) The ortho nitro analogue 3 was prepared as described in general procedure II using the ortho nitro pyrimidine 34 to obtain a yellowish brown solid in 72% (1.84 g) yield. TLC: Rf = 0.66 (DCM:MeOH, 25:1, v/v). 1H NMR (DMSO-d6, delta ppm): 8.38 (s, 1H), 8.23 (s, 1H), 8.21-8.18 (dd, J = 8.08 Hz, 1.44 Hz, 1H), 7.87 (dt, J = 8.30 Hz, 1H), 7.59 (m, 2H), 7.01 (br s, 1H), 6.48 (ds, 1H), 6.18 (br s, 1H), 3.68 (s, 3H), 3.06 (m, 4H), 2.43 (m, 4H), 2.21 (s, 3H). Anal.: Calcd for C22H23N6O4Cl: C, 56.11; H, 4.92; N, 17.85; Found: C, 55.99; H, 4.90; N, 17.80., 122833-04-9
122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Romu, Aireen A.; Lei, Zining; Zhou, Bin; Chen, Zhe-Sheng; Korlipara, Vijaya; Bioorganic and Medicinal Chemistry Letters; vol. 27; 21; (2017); p. 4832 – 4837;,
Piperazine – Wikipedia
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