With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16154-62-4,1-(2-Chloro-4-nitrophenyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.
To a solution of SG4-029 (2.00 g, 7.82 mmol) in MeOH (32 mL, deoxygenated with Argon gas) was added PtC (18 mg, 0.0782 mmol). A balloon of hydrogen gas was attached to the flask via a septum cap. The mixture was stirred at room temperature for 5 h. The reaction mixture was filtered over Celite and the filtrate concentrated under reduced pressure to provide the title compound as a light yellow solid (1.741 g, 98%). NMR (400 MHz, DMSO-ifc) delta: 6.85 (d, J = 8.5 Hz, 1H), 6.59 (d, / = 2.6 Hz, 1H), 6.45 (dd, / = 8.5, 2.6 Hz, 1H), 5.01 (s, 2H, disappeared on D20 shake), 2.81- 2.72 (m, 4H), 2.40 (brs, 4H), 2.18 (s, 3H). HPLC-MS (ESI+): m/z 228.2 [35%, (M37C1+H)+], 226.2 [100%, (M35C1+H)+]., 16154-62-4
The synthetic route of 16154-62-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas J.; LAWRENCE, Harshani R.; (293 pag.)WO2017/66428; (2017); A1;,
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