With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84477-72-5,2,2-Dimethylpiperazine,as a common compound, the synthetic route is as follows.,84477-72-5
To a solution of 2,2-dimethylpiperazine (400 mg) in dichloromethane (20 mL) at 0 C. was added di-tert-butyl dicarbonate (766 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL) and extracted into dichloromethane (2*40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4) and concentrated to give 3,3-diemethyl-piperazine-1-carboxylic acid tert-butyl ester as a white solid (720 mg, 96%).
The synthetic route of 84477-72-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Piramed Limited; Genentech, Inc.; US2008/76758; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics