With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2759-28-6,1-Benzylpiperazine,as a common compound, the synthetic route is as follows.
Synthesis of 1-(1,1-dimethylethoxycarbonyl)4-phenylmethylpiperazine STR30 A solution of 3.4 g (0.024 mole) of 1,1-dimethylethoxy carbonylazide in 5 ml of pyridine was rapidly added to a stirred solution of 1-phenylmethylpiperazine (4.2 g, 0.024 mole) in 5 ml of pyridine. An initial exothermic reaction was noted. The mixture was allowed to stir overnight, diluted with water and the product was extracted with two 50 ml portions of ether. The ether extracts were dried (MgSO4), filtered, and evaporated to yield a yellow oil. Column chromatography (2″ diameter column, 500 g of silica gel, ether eluent) followed by sublimation at 110/0.5 mm returned 5.7 g (86%) of white solid, m.p. 64-73. The solid was dissolved in 50 ml of ether and cooled to -70. The resultant white solid was filtered off to yield 4.5 g (68%) of product, m.p. 71-3. Calc. for C16 H24 N2 O2 (276.38): C, 69.53; H, 8.75; N, 10.14. Found: C, 69.44; H, 8.82; N, 10.15.
2759-28-6, 2759-28-6 1-Benzylpiperazine 75994, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ICI Americas Inc.; US4247549; (1981); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics