With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34770-60-0,4-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.
To a solution of 4-methyl-2-piperazinone (26.16 mg, 0.23 mmol) in N,N-dimethylformamide (3mL) was added sodium hydride (18.34 mg, 60% purity, 0.46 mmol) at 0 C. The reaction was stirred for 20 minutes at 0 C. 2-[[8-Chloro-6-(chloromethyl)-7-fluoro-3-isoquinolyl]amino]-6-isopropyl-5,8-dihydro-4H-pyrazolo[1,5-d][1,4]diazepin-7-one (50 mg, 0.11 mmol) was added and stirred at 25 C. for 1 hour. The reaction was quenched with water, extracted with ethyl acetate, dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under vacuum. The residue was purified by reverse phase chromatography ( acetonitrile 0-40/0.1% sodium bicarbonate in water) to afford 2-[[8-chloro-7-fluoro-6-[(4-methyl-2-oxo-piperazin-1-yl)methyl]-3-isoquinolyl]amino]-6-isopropyl-5,8-dihydro-4H-pyrazolo[1,5-d][1,4]diazepin-7-one (9 mg, 0.018 mmol) as a yellow solid. LCMS (ESI) [M+H]+=514.
As the paragraph descriping shows that 34770-60-0 is playing an increasingly important role.
Reference£º
Patent; Genentech, Inc.; Chan, Bryan; Drobnick, Joy; Gazzard, Lewis; Heffron, Timothy; Liang, Jun; Malhotra, Sushant; Mendonca, Rohan; Rajapaksa, Naomi; Stivala, Craig; Tellis, John; Wang, Weiru; Wei, BinQing; Zhou, Aihe; Cartwright, Matthew W.; Lainchbury, Michael; Gancia, Emanuela; Seward, Eileen; Madin, Andrew; Favor, David; Fong, Kin Chiu; Hu, Yonghan; Good, Andrew; US2018/282282; (2018); A1;,
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