With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: To the stirred solution of 3-(3-oxo-2H-benzo[b][1,4]thiazin-4(3H)-yl)propanoic acid (100mg, 0.448 mol) in DMF, N-phenyl piperzine derivatives (0.538 mol) or 3-(4-phenylpiperazin-1-yl)propan-1-amine derivatives (0.538 mol) was added at room temperature, followed by the addition of EDC:HCl (102 mg) and HOBt (60.5 mg), the stirring was continued for 12h. After completion of the reaction (TLC analysis), small amount of ice cold water (10 mL) was added to the reaction mixture and then extracted with chloroform (2 x 10 mL). The chloroform layer was separated, dried over Na2SO4 and evaporated under vacuum to give corresponding derivatives 8a-i and 10a-g in good yields., 30459-17-7
30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Venkatesh, Ramineni; Kasaboina, Suresh; Bidayat, Deepthi; Nikhil Kumar; Jain, Nishant; Tangeda, Saritha Jostna; Bantu, Rajashaker; Janardhan, Sridhara; Nagarapu, Lingaiah; Bioorganic and Medicinal Chemistry Letters; vol. 27; 2; (2017); p. 354 – 359;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics