Downstream synthetic route of 129779-30-2

129779-30-2, As the paragraph descriping shows that 129779-30-2 is playing an increasingly important role.

129779-30-2, (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The (2i?,65)-l-(iV-benzyloxycarbonylglycyl)-2,6-dimethylpiperazine used as a starting material was prepared as follows :-; Diisopropylethylamine (0.4 ml) was added to a stirred mixture of ter t-butyl (3i?,55)-3,5-dimethylpiperazine-l-carboxylate (0.25 g; available from Atlantic SciTech Group, Inc., 601 East Linden Avenue, Linden, New Jersey 07036, USA)), N- benzyloxycarbonylglycine (0.296 g), 2-(7-azabenzotriazol-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate (V) (0.555 g) and DMA (15 ml) and the resultant mixture was stirred at ambient temperature for 18 hours. The reaction mixture was evaporated and the residue was dissolved in a mixture of trifluoroacetic acid (1.5 ml) and methylene chloride (4.5 ml). The mixture was stirred at ambient temperature for 1 hour. The resultant mixture was evaporated. Methanol was added to the residue and the solution was loaded onto an Isolute SCX-2 cation exchange cartridge (20 g). The column was washed with methanol and the product was eluted using a 3M methanolic ammonia solution. There was thus obtained (2i?,6.S)-l-(N-benzyloxycarbonylglycyl)-2,6-dimethylpiperazine (0.46 g); Mass Spectrum: M+H+ 306; HPLC: method Bl, Retention Time 2.37 minutes.

129779-30-2, As the paragraph descriping shows that 129779-30-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/32064; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics