109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The starting material was ptepared as follows: 2-Bromoethanol (2.36 g, 19 mmol) was added dropwise to a mixture of 1-methylpiperazine (1.26 g, 13 mmol) and potassium carbonate (5.0 g, 36 mmol) in absolute ethanol (150 ml) and the mixture heated at reflux for 18 hours. The mixture was allowed to cool and the precipitates were removed by filtration and the solvent volatiles were removed by evaporation. The residue was treated with acetone/methylene chloride, the insolubles were removed by filtration and the solvent was removed from the filtrate by evaporation to give 1-(2-hydroxyethyl)-4-methylpiperazine (870 mg, 48percent) as a light brown oil. 1H NMR Spectrum: (CDCl3) 2.1 8(s, 3H); 2.3-2.7(br m, 8H); 2.56(t, 2H); 3.61 (t, 2H) MS-ESI: 145 [MH]+, 109-01-3
109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Zeneca Limited; Zeneca Pharma S.A.; US6291455; (2001); B1;,
Piperazine – Wikipedia
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