With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182618-86-6,1-Boc-4-(4-Nitrophenyl)piperazine,as a common compound, the synthetic route is as follows.
A solution of tert-butyl 4-(4-nitrophenyl)piperazine- 1 -carboxylate (8.2 g, 26.68 mmol) inMeOH (100 mL) was purged using nitrogen and reduced pressure. Palladium on charcoal(10% wet) was added and the mixture was hydrogenated (50 psi) for 16 h. The reaction mixture was filtered through diatomaceous earth and concentrated under reduced pressure to give tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (7.4 g, 97%) as a dark blue oil used directly into the next step. C15H23N302 MS m/z 277.9 (M+H)., 182618-86-6
As the paragraph descriping shows that 182618-86-6 is playing an increasingly important role.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BIGNAN, Gilles; CONNOLLY, Peter J.; HICKSON, Ian; MEERPOEL, Lieven; PANDE, Vineet; ZHANG, Zhuming; BRANCH, Jonathan; ROCABOY, Christian; TRABALON ESCOLAR, Luis B.; (521 pag.)WO2017/123542; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics