With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
General procedure: A mixture of Palladium() acetate (6mg, 0.22mmol) 2-dicyclohexylphosphino-2?,6? -di-i-porpoxy-1,1?-biphenyl (22mg, 0.044mmol), and cesium carbonate (0.22g, 0.68mmol) were weighted out and the vial was purged with nitrogen, the bromo-contained intermediate 8d (0.44mmol) and a series of N-containing heterocyclic compounds (0.68mmol) solved in 1,4-dioxane (15mL) were added. The mixture was stirred at 100C for 16h. The reaction was filtered, concentrated and purified by silica gel column chromatography to give 18a-38a.
13889-98-0, As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.
Reference£º
Article; Cao, Zhonglian; Fu, Wei; Ma, Xiaojun; Sun, Nannan; Wang, Yonghui; Xu, Jun; Zhou, Kaifeng; Zhu, Chen; European Journal of Medicinal Chemistry; vol. 187; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics