30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
At 0C under nitrogen, 366mg of commercially available 2-chloropyridine-4-carbonyl chloride dissolved in 2ml of dichloromethane were added dropwise to a solution of 530mg of commercially available 4-(1 -piperazinyl)-2-trifluoromethylbenzonitrile in 5ml ofdichloromethane and 630mg of Et3N. The reaction mixture was stirred overnight at room temperature, poured over a stirred mixture of 100ml EtOAc and 40ml of water. The aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine, dried over MgS04, filtered, concentrated under vacuum and purified by column chromatography on silica gel to isolate 620mg of 4-{4-[(2-chloropyridin-4-yl)carbonyl]piperazin-1 -yl}-2- (trifluoromethyl)benzonitrile. 99mg of this material were then added to a degased mixture of 85mg of commercially available 1 -(4-trifluoromethylphenyl)piperazine, 6mg of Pd(OAc)2, 23mg of RuPhos, 163mg of Cs2C03, and 1 .5ml of ie/f-Butanol then, heated to 85 C overnight. The reaction mixture was then poured at room temperature over a stirred mixture of 50ml of EtOAc and 10ml of water. The aqueous layer was extracted with 10ml EtOAc. The combined organic layers were washed with brine, dried over MgS04, filtered, concentrated under vacuum and purified by column chromatography to isolate 60mg of compound No. 32 in Table 2., 30459-17-7
30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NOVARTIS TIERGESUNDHEIT AG; GAUVRY, Noelle; PAUTRAT, Francois; WO2015/71417; (2015); A1;,
Piperazine – Wikipedia
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