With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Preparation of tert-butyl 4-(2-((3-cyano-4-(6-(4-methyl-4- (picolinamido)piperidin-l-yl)pyridin-3-yl)pyrazolo[l,5-a]pyridin-6-yl)oxy)ethyl)piperazine- 1-carboxylate. To a solution of N-(l-(5-(3-cyano-6-hydroxypyrazolo[l,5-a]pyridin-4- yl)pyridin-2-yl)-4-methylpiperidin-4-yl)picolinamide (Intermediate P90, 120 mg, 0.265 mmol) in DMA (2.646 mL) was added tert-Butyl 4-(2-chloroethyl)tetrahydro-l(2H)- pyrazinecarboxylate (65.8 mg, 0.265 mmol) and cesium carbonate (431 mg, 1.32 mmol). The reaction mixture was stirred at 60C for 48 h. After cooling to ambient temperature, the reaction mixture was diluted with 4: 1 DCM/IPA and washed successively with saturated NaHC03(aq) and saturated NaCl(aq). The organic extract was dried over anhydrous Na2S04(S), filtered, and concentrated in vacuo to afford the title compound (176 mg, 0.264 mmol, 99.9 % yield) in sufficient purity for step 2. MS (apci) m/z = 666.4 (M+H).
208167-83-3, The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
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