With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.
55121-99-8, To a stirred solution of triphosgene (0.373 mg, 1.258 lmol) in anhydr. THF (20 ml) was added 7d (S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline (1.200 mg, 2.097 lmol) at 25 C. The reaction mixture wasstirred for 5 min and NEt3 (45 mL, 0.33 mmol) were added and the reaction mixture was stirred for additional 1 h. Then 9a 4-amino-N-(2-(dimethylamino)ethyl)-N-methylbenzamide (1.392 mg, 6.29 lmol) was added and stirred for another 0.5 h and NEt3 (406 mL, 2.91 mmol) was added and the mixture was stirred over night. The solvents were removed in a N2 stream and the crude mixture was purified by semi-prep-HPLC to obtain 3 as an off white solid (665 mg, 53%).
The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Dehnhardt, Christoph M.; Venkatesan, Aranapakam M.; Chen, Zecheng; Delos-Santos, Efren; Ayral-Kaloustian, Semiramis; Brooijmans, Natasja; Yu, Ker; Hollander, Irwin; Feldberg, Larry; Lucas, Judy; Mallon, Robert; Bioorganic and Medicinal Chemistry Letters; vol. 21; 16; (2011); p. 4773 – 4778;,
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