150407-69-5, (S)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
150407-69-5, To a solution of piperazine carboxylic acid (10 g, 27 mmol) in DCM (50 mL) was added TEA (2.39 mL, 54 mmol) and HATU (11.4 g, 30 mmol) with stirring. The reaction mixture was stirred at room temperature for 30 mins then treated with piperidine (2.57 g, 30 mmol). The reaction solution was stirred for 48 hrs then concentrated. The residue was purified by columnchromatography on silica gel eluted with petroleum ether / EtOAc (3 : 1) to afford compound Tnt48-1 as yellow oil (10.7g). MS-ESI (mlz): 432 (M+1) Rf: 0.6 (PE : EtOAc= 1: 1) ?H NMR(CDC13) oe: 7.307.24 (m, 5H), 5.25 (s, 1H), 5.14 (d, J=12.3 Hz, 1H), 5.064.98 (m, 1H),4.183.80 (m, 5H), 3.41 (s, 2H), 3.21 (d, J13 Hz, 3H), 1.61 (s, 2H), 1.52 (t, J1=16.6 Hz,J214.7 Hz, 3H), 1.39 (s, 1OH).
The synthetic route of 150407-69-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; COBURN, Craig; MALETIC, Milana; LUO, Yunfu; QI, Zhiqi; YU, Tingting; SOLL, Richard; WO2015/70367; (2015); A1;,
Piperazine – Wikipedia
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