5464-12-0, 1-(2-Hydroxyethyl)-4-methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5464-12-0, Compound 31g S6-2d was added to the reaction flask under nitrogen protection.33g 1-hydroxyethyl-4-methylpiperazine, 60g of triphenylphosphine, inject 625mL of toluene, stir to dissolve, and then add52.7 g of di-tert-butyl azodicarboxylate,The reaction was heated to 50¡ãC and stirred for 2 hours.TLC showed that the compound S6-2d was completely reacted to produce the product S6-2e with increased polarity. After the treatment, 30percent hydrochloric acid in methanol was added and 300 mL was stirred at room temperature for two hours.Filtrate the filtrate,The cake was beaten with methyl tert-butyl ether to give a filtrate.Combine the filtrate dry powder mix,Column chromatography (dichloromethane/methanol=15/1) gave 22 g of a yellow liquid.That is, compound S6-2e with a yield of 57percent
As the paragraph descriping shows that 5464-12-0 is playing an increasingly important role.
Reference£º
Patent; Douchuang (Shanghai) Pharmaceutical Technology Co., Ltd.; Wang Lei; Wang Xiaolei; Wang Zongying; Chen Da; Cao Ruqi; (20 pag.)CN107573360; (2018); A;,
Piperazine – Wikipedia
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