163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of (R) -tert-butyl3-methylpiperazine-1-carboxylate (500 mg, 2.5 mmol) and triethylamine (700 mg,6.3 mmol) in DCM (10 mL) was added methylsulfamoyl chloride (0.39 mL,4.99 mmol) at 0 dropwise. The mixture was stirred at rt for 8 h, and washedwith water (10 mL ¡Á 3) . The combined organic layer were dried over anhydrousNa2SO4 and concentrated. The residue was purified bysilica gel chromatography eluted with Petroleum ether/EtOAc (v/v) 2/1 to give(R) -tert-butyl 3-methyl-4- (methylsulfonyl) piperazine-1-carboxylate as awhite solid (444 mg, 63) . 1H NMR (400 MHz, CDCl3): delta ppm 4.04-4.24 (m, 2H) , 3.82-3.98 (m, 1H) , 3.54 (d, J 12.7 Hz, 1H) ,3.14-3.21 (m, 1H) , 3.04-3.18 (m, 1H) , 2.87-3.00 (m, 1H) , 2.88 (s, 3H) , 1.48(s, 9H) , 1.26 (d, J 6.8 Hz, 3H) and MS-ESI: m/z 223.15 [M-55] +., 163765-44-4
The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
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