59702-07-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.
The indazole (810 mg), Et3N (3.9 g), and amine (1.9 g) were taken up in DMSO (4 ml). The resulting solution was heated in a sealed tube at 100 ¡ãC for 16 hours. The solution was cooled, and it was partitioned between EtOAc and water. The aqueous layer was extracted with EtOAc. The combined organic layers were dried (MgS04), filtered, and concentrated. The residue was purified by flash chromatography (30/1 DCM MeOH, Si02) which provided the amino-pyridine.
59702-07-7 1-Methylpiperazin-2-one 4399042, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; BASU, Kallol; DEMONG, Duane; SCOTT, Jack; LIU, Hong; DAI, Xing; STAMFORD, Andrew; POIRIER, Marc; TEMPEST, Paul; WO2014/134776; (2014); A1;,
Piperazine – Wikipedia
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