934-98-5,934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 15-chloro-3-(3-fury)-N-[2-(4-methylpiperazin-1-yl)ethyl]-1H-indole-2-carboxamideA DMF solution (340 mL) containing the compound obtained in Production example 1-3 (11.6 g), 2-(4-methylpiperazin-1-yl)ethylamine (7.0 g) and HATU (18.5 g) was ice-cooled to 15¡ã C., and diisopropylethylamine (23.2 mL) was added thereto and the resulting solution was stirred overnight at room temperature.The reaction solution was poured into water (1.5 L), and the mixture was stirred at room temperature for 5 minutes.A precipitate was collected by filtration and washed with water and then dissolved in chloroform (600 mL).The chloroform layer was washed with a saturated aqueous sodium hydrogen carbonate solution and then dried over anhydrous magnesium sulfate.The solvent was distilled off under reduced pressure, and the resulting residue was purified by NH-silica gel column chromatography (hexane:ethyl acetate=2:1 to 1:3), whereby the title compound (8.8 g) was obtained as a pale yellow solid.1H-NMR (400 MHz, CDCl3, deltappm): 2.30 (3H, s), 2.32-2.50 (8H, m), 2.47 (2H, t, J=5.8 Hz), 3.51 (2H, dt, J=5.8 Hz, 5.8 Hz), 6.63 (1H, dd, J=1.9, 0.9 Hz), 7.03 (1H, br s), 7.25 (1H, m), 7.39 (1H, dd, J=8.8 Hz, 0.6 Hz), 7.49 (1H, m), 7.66 (1H, m), 7.70 (1H, m), 9.78 (1H, s).ESI-MS Found: m/z 387[M+H]+
The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MSD K.K; US2012/28990; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics