With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.
Amixture of A2. C-2) (0.0002 mol) and 4-[(4-methyl-1-piperazinyl)methyl]-benzenamine (0.0004 mol) in DMSO (2 ml) was stirred for 3 hours at 80C and then the reaction mixture was stirred overnight at room temperature. The solvent was evaporated (Genevac) and the obtained residue was purified by high-performance liquid chromatograp hy. The product fractions were collected, then the solvent was evaporated and co-evaporated with CH3OH. Yield: 0.0119 g of final compound 80., 70261-82-4
The synthetic route of 70261-82-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/12304; (2005); A2;,
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