With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161357-89-7,1-(Methylsulfonyl)piperazine hydrochloride,as a common compound, the synthetic route is as follows.
1- (Methylsulfonyl) piperazine hydrochloride (1.07 mmol) was added to acetonitrile (5 ml) and potassium carbonate (1.16 mmol) was added followed by 3-phenylpropyl isocyanate (1.07 mmol). The reaction mixture was stirred at room temperature for 8 hours. After the reaction was completed, water was added and extracted with ethyl acetate. The organic layer was concentrated and purified by column chromatography to give the title compound., 161357-89-7
161357-89-7 1-(Methylsulfonyl)piperazine hydrochloride 16265612, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; The Industry & Academic Cooperation in Chungnam National University (IAC); Jung, Sang-Hun; Woo, Sun-Hee; Kim, Sang- Kyum; Jeon, Eun-Seok; Lee, Yu-Jung; Meunikam, Manoj; Jalani, Hiteshkumar; Sharma, Niti; (205 pag.)KR2016/108281; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics