With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
To a solution of 1 (0.31 g, 1.43 mmol) in THF (20 mL) was added Ti(OEt)4 (0.595 g, 2.58 mmol) and N-(4-trifluoromethylphenyl)-piperazine 2 (0.3 g, 1.3 mmol). The mixture was stirred at 40 C. for 24 h, quenched by adding ice-water, extracted with ethyl acetate (3¡Á20 mL), dried. Purification by column chromatography (PE/EA:1/1) gave product 3 (0.25 g, 41%).
30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; COGNITION THERAPEUTICS, INC.; Catalano, Susan M.; Rishton, Gilbert; Izzo, Nicholas J.; (109 pag.)US2017/197977; (2017); A9;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics